from Journal of the American Society of Nephrology current issue http://ift.tt/2kd5H...
Thursday, November 30, 2017
Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF-{beta} Receptor: A New Twist on an Old Paradigm
from Journal of the American Society of Nephrology current issue http://ift.tt/2BAho...
Obesity-Related CKD: When Kidneys Get the Munchies
from Journal of the American Society of Nephrology current issue http://ift.tt/2kd5E...
Prescription Opioids for Pain Management in Patients on Dialysis
from Journal of the American Society of Nephrology current issue http://ift.tt/2BAhl...
Calcineurin Inhibitors in the Treatment of Lupus Nephritis: A Hare Versus Turtle Story?
from Journal of the American Society of Nephrology current issue http://ift.tt/2kbTO...
Developing Tools for Analysis of Renal Genomic Data: An Invitation to Participate
from Journal of the American Society of Nephrology current issue http://ift.tt/2BAhh...
Dialysate Potassium, Dialysate Magnesium, and Hemodialysis Risk
One of the fundamental goals of the hemodialysis prescription is to maintain serum potassium levels within a narrow normal range during both the intradialytic and interdialytic intervals. Considering the extraordinarily high rate of cardiovascular mortality in the hemodialysis population, clinicians are obligated to explore whether factors related to dialytic potassium removal can be modified to improve clinical outcomes. Observational studies and...
New Ultrasound Techniques Promise Further Advances in AKI and CKD
AKI and CKD are important clinical problems because they affect many patients and the associated diagnostic and treatment paradigms are imperfect. Ultrasound is a cost-effective, noninvasive, and simple imaging modality that offers a multitude of means to improve the diagnosis, monitoring, and treatment of both AKI and CKD, especially considering recent advances in this technique. Ultrasound alone can attenuate AKI and prevent CKD by stimulating...
Assessing Microvascular Function in Humans from a Chronic Disease Perspective
Microvascular dysfunction (MVD) is considered a crucial pathway in the development and progression of cardiometabolic and renal disease and is associated with increased cardiovascular mortality. MVD often coexists with or even precedes macrovascular disease, possibly due to shared mechanisms of vascular damage, such as inflammatory processes and oxidative stress. One of the first events in MVD is endothelial dysfunction. With the use of different...
BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI
AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic...
Interference with Gs{alpha}-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage
Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored them for 6 months after induction at 6 weeks of age. The knockout mapped exclusively...
Blocking TGF-{beta} and {beta}-Catenin Epithelial Crosstalk Exacerbates CKD
The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many different cellular effects depending on the target cell type. To investigate how TGF-β signaling in the proximal tubule, a key target and mediator of CKD, alters the response to CKD, we injured mice lacking the...
Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis
Compared with males, females have lower BP before age 60, blunted hypertensive response to angiotensin II, and a leftward shift in pressure natriuresis. This study tested the concept that this female advantage associates with a distinct sexual dimorphic pattern of transporters along the nephron. We applied quantitative immunoblotting to generate profiles of transporters, channels, claudins, and selected regulators in both sexes and assessed the physiologic...
Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD
Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and dyslipidemia. Activating the renal cannabinoid-1 receptor (CB1R) induces nephropathy, whereas CB1R blockade improves kidney function. Whether these effects are mediated via a specific cell type within the kidney remains unknown. Here, we show that specific deletion of CB1R in the renal proximal...
Renal Tubular Cell-Derived Extracellular Vesicles Accelerate the Recovery of Established Renal Ischemia Reperfusion Injury
Ischemic renal injury is a complex syndrome; multiple cellular abnormalities cause accelerating cycles of inflammation, cellular damage, and sustained local ischemia. There is no single therapy that effectively resolves the renal damage after ischemia. However, infusions of normal adult rat renal cells have been a successful therapy in several rat renal failure models. The sustained broad renal benefit achieved by relatively few donor cells led to...
Kindlin-2 Association with Rho GDP-Dissociation Inhibitor {alpha} Suppresses Rac1 Activation and Podocyte Injury
Alteration of podocyte behavior is critically involved in the development and progression of many forms of human glomerular diseases. The molecular mechanisms that control podocyte behavior, however, are not well understood. Here, we investigated the role of Kindlin-2, a component of cell-matrix adhesions, in podocyte behavior in vivo. Ablation of Kindlin-2 in podocytes resulted in alteration of actin cytoskeletal organization, reduction of the levels...
Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension
FSGS, the most common primary glomerular disorder causing ESRD, is a complex disease that is only partially understood. Progressive sclerosis is a hallmark of FSGS, and genetic tracing studies have shown that parietal epithelial cells participate in the formation of sclerotic lesions. The loss of podocytes triggers a focal activation of parietal epithelial cells, which subsequently form cellular adhesions with the capillary tuft. However, in the...
Targeting Phospholipase D4 Attenuates Kidney Fibrosis
Phospholipase D4 (PLD4), a single-pass transmembrane glycoprotein, is among the most highly upregulated genes in murine kidneys subjected to chronic progressive fibrosis, but the function of PLD4 in this process is unknown. Here, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidneys after fibrosis. Genetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial...
Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest
Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process. In mice subjected to unilateral ureteral obstruction, genetic deletion or pharmacologic inhibition of MIF aggravated fibrosis and inflammation, whereas treatment with recombinant MIF was beneficial, even in established fibrosis. In two other...
Serum Iron Protects from Renal Postischemic Injury
Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury. In a retrospective cohort study of renal allograft recipients (n=169), increased baseline levels of serum ferritin reliably predicted a positive outcome for allografts, particularly in elderly patients....
Targeting Anti-TGF-{beta} Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach
Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic treatment has had limited success. We designed an approach to target an extracellular matrix protein, the fibronectin extra domain A isoform (FnEDA), which is relatively restricted in distribution to sites of tissue injury. In a mouse...
Variations in MicroRNA-25 Expression Influence the Severity of Diabetic Kidney Disease
Diabetic nephropathy is characterized by persistent albuminuria, progressive decline in GFR, and secondary hypertension. MicroRNAs are dysregulated in diabetic nephropathy, but identification of the specific microRNAs involved remains incomplete. Here, we show that the peripheral blood from patients with diabetes and the kidneys of animals with type 1 or 2 diabetes have low levels of microRNA-25 (miR-25) compared with those of their nondiabetic counterparts....
C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients
Iron deficiency (ID) is independently associated with an increased risk of death in renal transplant recipients (RTRs). ID promotes production and cleavage of intact fibroblast growth factor 23 (iFGF23) into C-terminal fibroblast growth factor 23 (cFGF23), elevated levels of which are also prospectively associated with adverse outcomes. We hypothesized that in RTRs, the relationship between ID and mortality is mediated by FGF23. We measured plasma...
Use and Outcomes of Kidneys from Donation after Circulatory Death Donors in the United States
Donation after circulatory death (DCD) donors are an important source of kidneys for transplantation, but DCD donor transplantation is less common in the United States than in other countries. In this study of national data obtained between 2008 and 2015, recovery of DCD kidneys varied substantially among the country’s 58 donor service areas, and 25% of DCD kidneys were recovered in only four donor service areas. Overall, 20% of recovered DCD kidneys...
Opioid Prescription, Morbidity, and Mortality in United States Dialysis Patients
Aggressive pain treatment was advocated for ESRD patients, but new Centers for Disease Control and Prevention guidelines recommend cautious opioid prescription. Little is known regarding outcomes associated with ESRD opioid prescription. We assessed opioid prescriptions and associations between opioid prescription and dose and patient outcomes using 2006–2010 US Renal Data System information in patients on maintenance dialysis with Medicare Part...
Multitarget Therapy for Maintenance Treatment of Lupus Nephritis
Our previous studies showed that multitarget therapy is superior in efficacy to intravenous cyclophosphamide as an induction treatment for lupus nephritis in Asian populations. We conducted an open label, multicenter study for 18 months as an extension of the prior induction therapy trial in 19 renal centers in China to assess the efficacy and safety of multitarget maintenance therapy in patients who had responded at 24 weeks during the induction...
The Clinical and Economic Effect of Vascular Access Selection in Patients Initiating Hemodialysis with a Catheter
Patients in the United States frequently initiate hemodialysis with a central venous catheter (CVC) and subsequently undergo placement of a new arteriovenous fistula (AVF) or arteriovenous graft (AVG). Little is known about the clinical and economic effects of initial vascular access choice. We identified 479 patients starting hemodialysis with a CVC at a large medical center (during 2004–2012) who subsequently had an AVF (n=295) or AVG (n=105) placed...
Tubulointerstitial Nephritis with IgM-Positive Plasma Cells
Infiltration by IgG-positive plasma cells is a common finding in tubulointerstitial nephritis. Indeed, it has been thought that CD138-positive mature plasma cells secrete mainly IgG, and the occurrence of tubulointerstitial nephritis with CD138-positive plasma cells secreting IgM has rarely been reported. Routine immunofluorescence of fresh frozen sections is considered the gold standard for detection of immune deposits. However, the immunoenzyme...
Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery
Clinical AKI, measured by serum creatinine elevation, is associated with long-term risks of adverse cardiovascular (CV) events and mortality in patients after cardiac surgery. To evaluate the relative contributions of urine kidney injury biomarkers and plasma cardiac injury biomarkers in adverse events, we conducted a multicenter prospective cohort study of 968 adults undergoing cardiac surgery. On postoperative days 1–3, we measured five urine biomarkers...
The Association of Sleep Duration and Quality with CKD Progression
Evidence suggests that sleep disorders are common in individuals with CKD, but the influence of sleep duration and quality on CKD progression is unknown. We examined the association of habitual sleep duration and quality with CKD progression in 431 Chronic Renal Insufficiency Cohort (CRIC) Study participants, of whom 48% were women and 50% had diabetes (mean age of 60 years old, mean eGFR =38 ml/min per 1.73 m2, and median urine protein-to-creatinine...
Without Obamacare Mandate, ‘You Open the Floodgates’ for Skimpy Health Plans
By REED ABELSON from NYT Health http://ift.tt/2Bz9W...
FOX NEWS: UMass Amherst declares meningitis outbreak after 2 confirmed cases
UMass Amherst declares meningitis outbreak after 2 confirmed cases
A Massachusetts university has declared a meningitis outbreak after two students tested positive for the bacterial illnes...
FOX NEWS: US says patient charity helped drugmakers, revokes approval
US says patient charity helped drugmakers, revokes approval
One of the largest U.S. patient assistance charities may close after the federal government revoked its authorization, citing findings that the group, mainly funded by pharmaceutical companies, enabled drugmakers to influence prescription...
FOX NEWS: Bodybuilding products sold online may be mislabeled or unsafe
Bodybuilding products sold online may be mislabeled or unsafe
Many bodybuilding products sold online are mislabeled and contain unapproved drugs and other ingredients that may not be safe, a new study suggest...
FOX NEWS: Forecast predicts over half of US children will be obese by age 35
Forecast predicts over half of US children will be obese by age 35
Nearly three in five children in the U.S. today are destined to be obese when they reach their 35th birthday, according to a new projectio...
FOX NEWS: Weirdest health stories of 2017
Weirdest health stories of 2017
From hospital mix-ups to cases that left doctors baffled, 2017 had it's fair share of wacky medical dram...
FOX NEWS: Man claims he contracted eye-eating parasite from amusement park water ride
Man claims he contracted eye-eating parasite from amusement park water ride
A Pennsylvania man and his wife have filed a lawsuit against an amusement park over claims that he contracted an eye-eating parasite after going on one of the water ride...
FOX NEWS: Wackiest health stories of 2017
Wackiest health stories of 2017
From hospital mix-ups to cases that left doctors baffled, 2017 had it's fair share of wacky medical dram...
FOX NEWS: Inspiration behind 'ice bucket challenge' dead at 46
Inspiration behind 'ice bucket challenge' dead at 46
The man who inspired the “ALS Ice Bucket Challenge” died on Saturday after a 14-year long battle with the diseas...
Wednesday, November 29, 2017
FOX NEWS: Woman photographed breast-feeding son at Disneyland goes viral
Woman photographed breast-feeding son at Disneyland goes viral
A photo of a California woman breastfeeding her child at Disneyland has gone viral and received some support but also some negative reaction...
FOX NEWS: Dog bone treats could be deadly for pets, FDA warns
Dog bone treats could be deadly for pets, FDA warns
Store-bought bone treats may be a dog’s favorite snack, but they could make pets seriously ill and even result in death, the Food and Drug Administration has warne...
FOX NEWS: CDC: HIV diagnoses improving, but progress varies
CDC: HIV diagnoses improving, but progress varies
Delays in the time between becoming infected with HIV and getting a diagnosis are shortening, helped by efforts to increase testing for the virus that causes AIDS, U.S. health officials sai...
FOX NEWS: Utah hepatitis A outbreak hits 95 cases
Utah hepatitis A outbreak hits 95 cases
The Utah Department of Health is grappling with a growing hepatitis A outbreak that has reached 95 cases, with over 60 percent of patients requiring hospitalizatio...
FOX NEWS: Judge: Doctor who doesn't use computer can't regain license
Judge: Doctor who doesn't use computer can't regain license
A New Hampshire judge has denied an 84-year-old doctor's request to regain her license to practice, which she had surrendered partly over her inability to use a compute...
FOX NEWS: Radio contest helps 11-year-old battling brain cancer get Christmas tree
Radio contest helps 11-year-old battling brain cancer get Christmas tree
A local radio contest is helping to bring cheer to one Indiana family whose 11-year-old sibling is battling stage four brain cance...
Tuesday, November 28, 2017
FOX NEWS: Study finds commonality in 61 percent of opioid deaths
Study finds commonality in 61 percent of opioid deaths
As the staggering toll—in terms of bodies, emotions, money, and our life expectancy—of the opioid epidemic comes into sharper focus, the idea of those who are most at risk is crystallizing, too, thanks to research out of Columbia University Medical Cente...
FOX NEWS: Mom walks out of hospital days after breaking vertebrae in freak gymnastics accident
Mom walks out of hospital days after breaking vertebrae in freak gymnastics accident
A Utah mother said doctors told her family members there was a 96 percent chance she would be a quadriplegic or dead after they discovered her C-1 vertebrae fractured in four separate place...
FOX NEWS: Massachusetts baby gets life-saving liver transplant from New Hampshire police officer
Massachusetts baby gets life-saving liver transplant from New Hampshire police officer
Sloane St. James’ parents said they noticed something was amiss with their baby girl when she was around 4 months ol...
FOX NEWS: CDC urges consumers who drank raw milk product to seek treatment
CDC urges consumers who drank raw milk product to seek treatment
Health officials are urging anyone who has consumed raw milk within the last six months to seek medical attention after a New Jersey woman was infected with a rare bacteria earlier this yea...
FOX NEWS: Confused VA failed to report potentially dangerous doctors, may have put lives at risk, watchdog says
Confused VA failed to report potentially dangerous doctors, may have put lives at risk, watchdog says
The Department of Veterans Affairs is under fire for possibly putting lives at risk after a government watchdog report revealed that it failed to report 90 percent of potentially dangerous medical providers in recent year...
FOX NEWS: Tens of thousands dying from $30B fake drugs trade, WHO says
Tens of thousands dying from $30B fake drugs trade, WHO says
One in 10 drugs sold in developing countries is fake or substandard, leading to tens of thousands of deaths, many of them of African children given ineffective treatments for pneumonia and malaria, health officials said on Tuesda...
Monday, November 27, 2017
FOX NEWS: Boy born without arms or legs walks for first time in viral video
Boy born without arms or legs walks for first time in viral video
“Cambden, I’m so proud of you buddy...
FOX NEWS: 5 ways you're damaging your hearing
5 ways you're damaging your hearing
What did you sa...
Therapy for Sexual Misconduct? It’s Mostly Unproven
By BENEDICT CAREY from NYT Health http://ift.tt/2AeZH...
Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage
By GINA KOLATA from NYT Health http://ift.tt/2i8bY...
FOX NEWS: Disabled veteran helps deliver daughter on sidewalk
Disabled veteran helps deliver daughter on sidewalk
The birth of a baby is a momentous occasion for any family, but for one disabled veteran and his fiancé where and how their daughter was born has made it all the more specia...
FOX NEWS: Patient undergoes emergency surgery after dentist drops metal file down throat
Patient undergoes emergency surgery after dentist drops metal file down throat
A grandfather has spoken of his horror after ending up in hospital to have a serrated metal file removed from his stomach following a routine dental procedur...
FOX NEWS: Man complaining of abdominal pain has 263 coins, 100 nails removed from stomach
Man complaining of abdominal pain has 263 coins, 100 nails removed from stomach
Surgeons treating a man with suspected food poisoning were stunned to discover 263 coins and 100 nails in his stomac...
FOX NEWS: Brain damage from football concussions varies by position and career duration
Brain damage from football concussions varies by position and career duration
Football players may experience different degrees of brain damage after concussions depending on what position they play and how long they stick with the sport, a small U.S. study suggest...
Sunday, November 26, 2017
As Health Care Changes, Insurers, Hospitals and Drugstores Team Up
By REED ABELSON from NYT Health http://ift.tt/2AAvg...
FOX NEWS: Indiana ‘Night Nurse’ whose tweet about white women sparked investigation 'no longer' with hospital
Indiana ‘Night Nurse’ whose tweet about white women sparked investigation 'no longer' with hospital
A nurse at one of the largest hospital systems in the nation who sparked an internal investigation after posting a controversial tweet reportedly "is no longer an employee" at Indiana University Healt...
FOX NEWS: Indiana ‘Night Nurse’ says white women raising sons who are ‘rapists’ and ‘killers,’ sparking probe
Indiana ‘Night Nurse’ says white women raising sons who are ‘rapists’ and ‘killers,’ sparking probe
A controversial tweet allegedly posted Friday by a nurse at one of the largest hospital systems in the nation has sparked an internal investigatio...
Saturday, November 25, 2017
FOX NEWS: Couple gets wedding reception do-over after bride's health scare
Couple gets wedding reception do-over after bride's health scare
A New Jersey couple who had to leave their wedding reception early after the bride suffered an allergic reaction is getting a second celebration for fre...
Friday, November 24, 2017
Older Voters Stymied by Tighter ID Requirements
By PAULA SPAN from NYT Health http://ift.tt/2zlTI...
FOX NEWS: Why many pregnant women aren't screened for deadly skin cancers
Why many pregnant women aren't screened for deadly skin cancers
A new report finds that swaths of pregnant women are having to wait too long for treatment of deadly melanoma. The lag puts not just one, but two lives at ris...
Thursday, November 23, 2017
FOX NEWS: Abortion rates in US hit historic low, CDC report finds
Abortion rates in US hit historic low, CDC report finds
Abortion rates in the United States have fallen to a historic low, according to the latest data compiled by the Centers for Disease Control and Preventio...
FOX NEWS: Paramedics grant patient's last wish: one final beach day
Paramedics grant patient's last wish: one final beach day
A palliative care patient in Queensland, Australia, had a final wish: to see the ocean one more time before she die...
FOX NEWS: How to avoid listeria and other diseases while flying for the holidays
How to avoid listeria and other diseases while flying for the holidays
Close to 50 million Americans traveled for Thanksgiving last year. If you're on a plane for the holidays, here's some tips on how to avoid getting si...
Wednesday, November 22, 2017
Thanks a Lot! New Reasons Not to Eat Cookie Dough
By JAN HOFFMAN from NYT Health http://ift.tt/2jh2t...
FOX NEWS: Toddler receives kidney transplant after initial procedure stalled over dad's probation violation, family says
Toddler receives kidney transplant after initial procedure stalled over dad's probation violation, family says
A toddler who was born without kidneys finally received a life-saving transplant on Wednesday, more than a month after his initial procedure was stalled when his father – a perfect match for him – violated his probation, the boy’s mother...
Abnormal Proteins Discovered in Skin of Patients With Rare Brain Disease
By DENISE GRADY from NYT Health http://ift.tt/2zeNo...
FOX NEWS: Mom, boyfriend gave baby marijuana after she broke her leg, police say
Mom, boyfriend gave baby marijuana after she broke her leg, police say
Tessa Rose Murray and Nerrell McCoy of Muncie, Ind., were arrested Monday after they failed to seek treatment for their infant daughter’s broken leg and instead gave her marijuana to treat the pai...
FOX NEWS: Baby born 5 weeks early shares birthday with mom, grandma
Baby born 5 weeks early shares birthday with mom, grandma
A newborn’s Nov. 19 arrival marked a special date in his family’s calendar for a number of reasons, including that he now shares a birth with his mother and maternal grandmothe...
FOX NEWS: Health company fires 69 employees over refusal to get flu shots, report says
Health company fires 69 employees over refusal to get flu shots, report says
A Minnesota-based health care company has fired 69 employees who failed to comply with its flu shot mandate by the Nov. 10 deadlin...
Estradiol and Age-Related Bone Loss in Men
from Physiological Reviews current issue http://ift.tt/2zqNF...
Endothelial Cell Metabolism
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases. Recently, a new concept arose by which EC metabolism drives angiogenesis in parallel to well-established angiogenic growth factors (e.g., vascular endothelial growth factor). 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3-driven glycolysis...
Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained major risk for future long-duration spaceflight. NASA recently redefined this syndrome as Spaceflight-Associated Neuro-ocular Syndrome (SANS). Evidence thus reviewed supports that chronic, mildly elevated intracranial pressure (ICP) in space (as opposed to more variable ICP with posture and activity on Earth) is largely accounted for by loss of hydrostatic pressures...
FOX NEWS: FDA approves first 2-drug HIV regimen
FDA approves first 2-drug HIV regimen
The U.S. Food and Drug Administration on Tuesday approved the first two-drug regimen to treat HIV, the virus that causes AIDS, aimed at easing the side effects for long-term patients who are on the standard treatment involving three or more drug...
FOX NEWS: VA study shows parasite from Vietnam may be killing vets
VA study shows parasite from Vietnam may be killing vets
A half century after serving in Vietnam, hundreds of veterans have a new reason to believe they may be dying from a silent bullet — test results show some men may have been infected by a slow-killing parasite while fighting in the jungles of Southeast Asi...
FOX NEWS: Holiday party leftovers: What to keep and what to toss
Holiday party leftovers: What to keep and what to toss
Q&A with Dr. Manny: I just had a big holiday party, are there any leftovers I shouldn’t keep to avoid getting sic...
Estradiol and Age-Related Bone Loss in Men
from Physiological Reviews recent issues http://ift.tt/2zqNF...
Endothelial Cell Metabolism
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases. Recently, a new concept arose by which EC metabolism drives angiogenesis in parallel to well-established angiogenic growth factors (e.g., vascular endothelial growth factor). 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3-driven glycolysis...
Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained major risk for future long-duration spaceflight. NASA recently redefined this syndrome as Spaceflight-Associated Neuro-ocular Syndrome (SANS). Evidence thus reviewed supports that chronic, mildly elevated intracranial pressure (ICP) in space (as opposed to more variable ICP with posture and activity on Earth) is largely accounted for by loss of hydrostatic pressures...
Tuesday, November 21, 2017
FOX NEWS: Formerly conjoined twins at Philadelphia hospital released before holidays
Formerly conjoined twins at Philadelphia hospital released before holidays
Formerly conjoined twins who had spent more than a year at a hospital in Pennsylvania were discharged Tuesday, just in time to be home for Thanksgivin...
FOX NEWS: Salmonella poisoning symptoms and warning signs
Salmonella poisoning symptoms and warning signs
Eating food that’s contaminated with salmonella bacteria may cause you to be ill and experience discomfort for several day...
