Baby surprise: Woman mistakes 37-week pregnancy for bad Chinese food
A woman who thought she had bad Chinese food had the surprise of her life when she discovered she was actually pregnan...
Saturday, March 31, 2018
FOX NEWS: Teen battling cancer crowned honorary prom queen by South Carolina high school
Teen battling cancer crowned honorary prom queen by South Carolina high school
A 14-year-old girl from Barnwell, South Carolina, who's battling cancer was crowned honorary prom queen on Thursda...
Is This Tissue a New Organ? Maybe. A Conduit for Cancer? It Seems Likely.
By JACEY FORTIN from NYT Health https://ift.tt/2pUkj...
Friday, March 30, 2018
FOX NEWS: Synthetic pot cases spike in Illinois, officials warn users may experience 'bleeding from eyes and ears'
Synthetic pot cases spike in Illinois, officials warn users may experience 'bleeding from eyes and ears'
Emergency rooms in Illinois are noticing a recent spike in synthetic pot users who are suffering from "severe bleeding" and state health officials are warning the public to remain vigilan...
This Months Highlights
from Journal of the American Society of Nephrology current issue https://ift.tt/2GGFV...
Unique Gene Expression in Developing Ascending Vasa Recta: A Tale of Tie
from Journal of the American Society of Nephrology current issue https://ift.tt/2E85a...
Maintenance and Breakdown of Glomerular Tuft Architecture
from Journal of the American Society of Nephrology current issue https://ift.tt/2GXus...
We AIM2 Inflame
from Journal of the American Society of Nephrology current issue https://ift.tt/2pRsX...
Evaluation of Potential Living Kidney Donors in the APOL1 Era
from Journal of the American Society of Nephrology current issue https://ift.tt/2H0vC...
Gender Disparities and Financial Barriers to Living Kidney Donation
from Journal of the American Society of Nephrology current issue https://ift.tt/2E6rP...
Targeting Zero Infections in Dialysis: New Devices, Yes, but also Guidelines, Checklists, and a Culture of Safety
from Journal of the American Society of Nephrology current issue https://ift.tt/2GZBo...
Bariatric Surgery and Kidney Health
from Journal of the American Society of Nephrology current issue https://ift.tt/2E6Ja...
Filtering the Evidence: Is There a Cognitive Cost of Hemodialysis?
from Journal of the American Society of Nephrology current issue https://ift.tt/2GYyA...
HIV-Positive Kidney Donor Selection for HIV-Positive Transplant Recipients
The risks associated with transplanting HIV-positive kidneys into HIV-positive recipients have not been well studied. Since 2008, 43 kidneys from 25 HIV-positive deceased donors have been transplanted into patients who are HIV positive in Cape Town, South Africa. Among the donors, 19 (76%) died secondary to trauma. The average age for donors was 34 (interquartile range, 19–52) years old. In some donors, only one kidney was used because of a limited...
Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels
Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent multiplication mechanism. Medullary hyperosmolarity is protected from washout by countercurrent exchange and efficient removal of interstitial fluid resorbed from the loop of Henle and collecting ducts. In most tissues, lymphatic vessels drain excess interstitial fluid back to the venous circulation. However,...
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes
Adiponectin exerts renoprotective effects against diabetic nephropathy (DN) by activating the AMP-activated protein kinase (AMPK)/peroxisome proliferative-activated receptor–α (PPARα) pathway through adiponectin receptors (AdipoRs). AdipoRon is an orally active synthetic adiponectin receptor agonist. We investigated the expression of AdipoRs and the associated intracellular pathways in 27 patients with type 2 diabetes and examined the effects of...
Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli
A critical aspect of kidney function occurs at the glomerulus, the capillary network that filters the blood. The glomerular basement membrane (GBM) is a key component of filtration, yet our understanding of GBM interactions with mesangial cells, specialized pericytes that provide structural stability to glomeruli, is limited. We investigated the role of nephronectin (Npnt), a GBM component and known ligand of α8β1 integrin. Immunolocalization and...
The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential
The complement system is essential for host defense, but uncontrolled complement system activation leads to severe, mostly renal pathologies, such as atypical hemolytic uremic syndrome or C3 glomerulopathy. Here, we investigated a novel combinational approach to modulate complement activation by targeting C3 and the terminal pathway simultaneously. The synthetic fusion protein MFHR1 links the regulatory domains of complement factor H (FH) with the...
Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection
Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To identify changes in mitochondria protein expression in response to ischemic preconditioning, we isolated mitochondria from ischemic preconditioned kidneys and sham-treated kidneys as a basis for comparison. The proteomic...
FOX NEWS: Twin brothers in Michigan welcome newborns on the same day: 'It was destined to be'
Twin brothers in Michigan welcome newborns on the same day: 'It was destined to be'
Twin brothers in Michigan had an unexpected surprise on Tuesday when both of their wives gave birth on the same da...
Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD
Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is expressed in the kidney and activated mainly by macrophages. We investigated the potential pathogenic role of the AIM2 inflammasome in kidney disease. In kidneys from patients with diabetic or nondiabetic CKD, immunofluorescence showed AIM2 expression in glomeruli, tubules, and infiltrating...
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis
Renal ammonia metabolism is the primary mechanism through which the kidneys maintain acid-base homeostasis, but the molecular mechanisms regulating renal ammonia generation are unclear. In these studies, we evaluated the role of the proximal tubule basolateral plasma membrane electrogenic sodium bicarbonate cotransporter 1 variant A (NBCe1-A) in this process. Deletion of the NBCe1-A gene caused severe spontaneous metabolic acidosis in mice. Despite...
Protein Kinase 2{beta} Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction
Nonobstructive hydronephrosis, defined as dilatation of the renal pelvis with or without dilatation of the ureter, is the most common antenatal abnormality detected by fetal ultrasound. Yet, the etiology of nonobstructive hydronephrosis is poorly defined. We previously demonstrated that defective development of urinary tract pacemaker cells (utPMCs) expressing hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) and the stem cell...
IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation
The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-specific autoimmunity. Most studies have focused on the founding member of the IL-17 family, IL-17A, as the central mediator of diseases. Indeed, although pathogenic functions have been ascribed to IL-17A and IL-17F in the context of immune-mediated glomerular diseases, the specific functions of the other IL-17 family members in immunity and inflammatory kidney...
Impairment of PPAR{alpha} and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging
Defects in the renal fatty acid oxidation (FAO) pathway have been implicated in the development of renal fibrosis. Although, compared with young kidneys, aged kidneys show significantly increased fibrosis with impaired kidney function, the mechanisms underlying the effects of aging on renal fibrosis have not been investigated. In this study, we investigated peroxisome proliferator–activated receptor α (PPARα) and the FAO pathway as regulators of...
Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells
Cellular senescence is associated with renal disease progression, and accelerated tubular cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying mechanism is unknown. We assessed the potential role of Wnt9a in tubular cell senescence and renal fibrosis. Compared with tubular cells of normal subjects, tubular cells of humans with a variety of nephropathies and those of several mouse models of CKD expressed high levels...
Fibroblast-Specific {beta}-Catenin Signaling Dictates the Outcome of AKI
AKI is a devastating condition with high morbidity and mortality. The pathologic features of AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this study, we investigated the role of fibroblast-specific β-catenin signaling in dictating the outcome of AKI, using conditional knockout mice in which β-catenin was specifically...
Endogenous IL-33 Contributes to Kidney Ischemia-Reperfusion Injury as an Alarmin
Inflammation is a prominent feature of ischemia-reperfusion injury (IRI), which is characterized by leukocyte infiltration and renal tubular injury. However, signals that initiate these events remain poorly understood. We examined the role of the nuclear alarmin IL-33 in tissue injury and innate immune response triggered by experimental kidney ischemia-reperfusion. In wild-type mice, we found that IL-33 was constitutively expressed throughout the...
Effect of Bariatric Surgery on CKD Risk
Obesity is linked to the development and progression of CKD, but whether bariatric surgery protects against CKD is poorly understood. We, therefore, examined whether bariatric surgery influences CKD risk. The study included 2144 adults who underwent bariatric surgery from March of 2006 to April of 2009 and participated in the Longitudinal Assessment of Bariatric Surgery-2 Study cohort. The primary outcome was CKD risk categories as assessed by the...
The Change in Living Kidney Donation in Women and Men in the United States (2005-2015): A Population-Based Analysis
The factors underlying the decline in living kidney donation in the United States since 2005 must be understood to inform strategies to ensure access to this option for future patients. Population-based estimates provide a better assessment of donation activity than do trends in the number of living donor transplants. Using data from the Scientific Registry of Transplant Recipients and the United States Census, we determined longitudinal changes...
APOL1 Genotype and Renal Function of Black Living Donors
Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal function in black living kidney donors and evaluated whether this genotype alters the association between donation and donor outcome. We grouped 136 black living kidney donors as APOL1 high-risk (two risk alleles; n=19; 14%) or low-risk (one or zero risk alleles; n=117; 86%) genotype....
Hemodialysis Induces an Acute Decline in Cerebral Blood Flow in Elderly Patients
The initiation of hemodialysis is associated with an accelerated decline of cognitive function and an increased incidence of cerebrovascular accidents and white matter lesions. Investigators have hypothesized that the repetitive circulatory stress of hemodialysis induces ischemic cerebral injury, but the mechanism is unclear. We studied the acute effect of conventional hemodialysis on cerebral blood flow (CBF), measured by [15O]H2O positron emission...
Blood HER2 and Uromodulin as Causal Mediators of CKD
Many biomarkers have been epidemiologically linked with CKD; however, the possibility that such associations are due to reverse causation or confounding limits the utility of these biomarkers. To overcome this limitation, we used a Mendelian randomization (MR) approach to identify causal mediators of CKD. We performed MR by first identifying genetic determinants of 227 serum protein biomarkers assayed in 4147 participants of the Outcome Reduction...
Cluster-Randomized Trial of Devices to Prevent Catheter-Related Bloodstream Infection
Central venous catheters (CVCs) contribute disproportionately to bloodstream infection (BSI) and, by extension, to infection-related hospitalization, mortality, and health care costs in patients undergoing dialysis. Recent product advancements may reduce BSIs, but a sufficiently powered comparative-effectiveness study is needed to facilitate evidence-based patient care decisions. In a 13-month, prospective, cluster-randomized, open-label trial, we...
FOX NEWS: 7-year-old boy with Tourette's makes powerful video to stop teasing from classmates
7-year-old boy with Tourette's makes powerful video to stop teasing from classmates
A 7-year old boy with Tourette's Syndrome made a powerful video explaining the condition in an effort to stop his classmates from teasing hi...
Bologna Blamed in Worst Listeria Outbreak in History
By EMILY BAUMGAERTNER from NYT Health https://ift.tt/2GpOm...
FOX NEWS: Cancer experts say coffee is safe, despite California's new warning label requirement
Cancer experts say coffee is safe, despite California's new warning label requirement
A California court judge’s ruling ordering coffee companies to put cancer warning labels on their products is not changing the minds of scientists and health professionals who say there is no credible evidence to warrant the dramatic mov...
FOX NEWS: Boy's delight over new wheelchair swing at park will warm your heart
Boy's delight over new wheelchair swing at park will warm your heart
A boy in a wheelchair is filled with joy after having the chance to play on the swings at a neighborhood par...
FOX NEWS: Baby surprise: Woman mistakes 37-week pregnancy for bad Chinese food
Baby surprise: Woman mistakes 37-week pregnancy for bad Chinese food
A woman who thought she had bad Chinese food had the surprise of her life when she discovered she was actually pregnan...
FOX NEWS: CDC director pledges to bring opioid epidemic 'to its knees'
CDC director pledges to bring opioid epidemic 'to its knees'
Dr. Robert Redfield, Jr, the new CDC new director pledged Thursday to work to bring the nation's opioid epidemic "to its knees" and said he believes the AIDS epidemic could be ended in three to seven year...
Many Americans Try Retirement, Then Change Their Minds
By PAULA SPAN from NYT Health https://ift.tt/2Gktb...
Thursday, March 29, 2018
FOX NEWS: Bullied Oklahoma boy, 7, adopts rescue cat with same rare eye condition and cleft lip
Bullied Oklahoma boy, 7, adopts rescue cat with same rare eye condition and cleft lip
Madden Humphreys and his newly-adopted rescue cat, Moon, were destined to be friend...
FOX NEWS: Coffee needs cancer warning in California, judge rules
Coffee needs cancer warning in California, judge rules
A Los Angeles judge has ruled that coffee companies need to carry a cancer warning label in Californi...
FOX NEWS: Man may find a new kidney thanks to a shopping visit to Costco
Man may find a new kidney thanks to a shopping visit to Costco
An 18-year-old girl saw him and is helping him crowdsource an organ through social medi...
FOX NEWS: Twin brothers in Michigan welcome newborns on the same day: 'It was destined to be'
Twin brothers in Michigan welcome newborns on the same day: 'It was destined to be'
Twin brothers in Michigan had an unexpected surprise on Tuesday when both of their wives gave birth on the same da...
FOX NEWS: Mother turns her placenta into a smoothie and feeds it to her family for health benefits
Mother turns her placenta into a smoothie and feeds it to her family for health benefits
A woman turned her placenta into a smoothie and fed it to her husband and their 3-year-old son for what she believes are the health benefit...
FOX NEWS: Former NFL star Jim Kelly recovering after 12 hours of cancer surgery
Former NFL star Jim Kelly recovering after 12 hours of cancer surgery
Former NFL quarterback Jim Kelly was recovering Wednesday night in a New York City hospital after undergoing nearly 12 hours of surgery for oral cance...
Wednesday, March 28, 2018
FOX NEWS: Surgeons amazed after removing over 2,000 gallstones from woman
Surgeons amazed after removing over 2,000 gallstones from woman
Doctors are amazed after removing 2,350 stones from a woman's gallbladde...
FOX NEWS: Doctors remove 30-pound tumor from man's beer belly
Doctors remove 30-pound tumor from man's beer belly
A man who thought he had a big belly actually had a 30-pound cancerous tumor growing in his abdome...
FOX NEWS: Poisoned Russian ex-spy, daughter have slim chance of surviving, niece says
Poisoned Russian ex-spy, daughter have slim chance of surviving, niece says
The former Russian spy and his daughter poisoned by a military-grade nerve agent in Britain earlier this month have a slim chance on surviving, his niece sai...
FOX NEWS: Toddler hospitalized with severe blisters from toy makeup kit making recovery
Toddler hospitalized with severe blisters from toy makeup kit making recovery
Lydia’s reaction was first reported in a Facebook post by her parents 24 hours after using the makeup. It went vira...
FOX NEWS: Chemical spill at Chicago-area medical clinic sends at least 15 to hospital
Chemical spill at Chicago-area medical clinic sends at least 15 to hospital
A chemical spill Tuesday at a suburban Chicago medical clinic sent at least 15 people to hospitals, including employees and patrons, authorities sai...
Tuesday, March 27, 2018
FOX NEWS: Missouri man's sudden death during Colorado family ski trip sparks social media movement
Missouri man's sudden death during Colorado family ski trip sparks social media movement
It was the "perfect storm," Jim Flath says of his 26-year-old son's sudden death during a family ski vacation in Colorado last wee...
FOX NEWS: New organ called 'interstitium' may explain how cancer spreads, study says
New organ called 'interstitium' may explain how cancer spreads, study says
A group of scientists recently discovered an organ called the interstitium. It may help to explain how cancer spread...
FOX NEWS: Colorado hospitals cut opioid use by 36 percent in 6 months
Colorado hospitals cut opioid use by 36 percent in 6 months
Researchers find pilot program drastically reduced opioid use in emergency rooms; Alicia Acuna reports from Denve...
FOX NEWS: Pregnant woman discovered she had a tumor ‘as big as her baby’
Pregnant woman discovered she had a tumor ‘as big as her baby’
40-year-old Susan O'Flanagan was 20-weeks pregnant when the 14cm cancerous tumor was detected on her right kidney during a routine ultrasoun...
FOX NEWS: Huge scare for pregnant woman when scan revealed she had a tumor 'as big as her baby'
Huge scare for pregnant woman when scan revealed she had a tumor 'as big as her baby'
A pregnant woman had a huge scare when a scan revealed she had a tumor “as big as her baby...
FOX NEWS: Yucky ducky? Study reveals bath-time toy's dirty secret
Yucky ducky? Study reveals bath-time toy's dirty secret
The Swiss Federal Institute of Aquatic Science and Technology says researchers turned up “dense growths of bacteria and fungi” on the insides of toys like rubber ducks and crocodile...
FOX NEWS: A woman with vitiligo goes makeup-free after 30 years of 'wearing a mask'
A woman with vitiligo goes makeup-free after 30 years of 'wearing a mask'
A woman with a heart-shaped vitiligo patch on her face finds the courage to go makeup-free after 30 years of "wearing a mask...
FOX NEWS: ObamaCare premiums may impact the midterm elections
ObamaCare premiums may impact the midterm elections
Dr Nicole Saphier speaks out on 'Fox & Friends First...
FOX NEWS: Facebook more addictive than opioids?
Facebook more addictive than opioids?
As Facebook denies secretly collecting phone and data history on its users, there are concerns that the social media platform can be more addictive than opioids. #Tuck...
FOX NEWS: A woman with a blotchy skin disease finds the courage to go makeup-free after 30 years of 'wearing a mask'
A woman with a blotchy skin disease finds the courage to go makeup-free after 30 years of 'wearing a mask'
A woman with a heart-shaped vitiligo patch on her face has told how she finally found the courage to go makeup-free after 30 years of "wearing a mask...
Medicare Is Cracking Down on Opioids. Doctors Fear Pain Patients Will Suffer.
By JAN HOFFMAN from NYT Health https://ift.tt/2pJ3F...
FOX NEWS: Some e-cigarette users may struggle to quit smoking
Some e-cigarette users may struggle to quit smoking
Smokers who say they want to kick the habit might have an easier time if they don't use e-cigarettes, a U.S. study suggest...
Monday, March 26, 2018
Grindr, Popular Gay Sex App, to Offer H.I.V. Test Reminders
By DONALD G. McNEIL Jr. from NYT Health https://ift.tt/2IWYJ...
FOX NEWS: Short bursts of exercise may be as beneficial as regular workouts in extending life
Short bursts of exercise may be as beneficial as regular workouts in extending life
New research suggests that more than 20 minutes of daily exercise is necessary to reduce mortality and the risk of disease. But the good news is that the exercise can provide all these benefits even when broken down into short bursts of activit...
For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It?
By GINA KOLATA from NYT Health https://ift.tt/2Gewv...
FOX NEWS: A 380-lb girl with a genetic disorder that causes constant hunger crowned a pageant queen
A 380-lb girl with a genetic disorder that causes constant hunger crowned a pageant queen
A 15-year-old girl who weighs 380lbs due to a rare condition, called Prader-Willi Syndrome, has been crowned a pageant quee...
FOX NEWS: Fertility clinic rules out inappropriate access to tank area
Fertility clinic rules out inappropriate access to tank area
An Ohio fertility clinic where thousands of frozen eggs and embryos may have been damaged in a storage tank failure says it's ruled out any inappropriate physical access to its storage tanks are...
FOX NEWS: Obesity tied to shorter life, overweight people more years with heart disease
Obesity tied to shorter life, overweight people more years with heart disease
Obese people have shorter lives and even those who are just overweight spend more years living with heart disease than individuals who are a healthy weight, a U.S. study suggest...
Friday, March 23, 2018
Why Can’t Dying Patients Get the Drugs They Want?
By KATIE THOMAS from NYT Health https://ift.tt/2DQDy...
FOX NEWS: Woman who couldn't open her mouth for 30 years is finally able to chew
Woman who couldn't open her mouth for 30 years is finally able to chew
A woman has eaten solid food for the first time in 30 years after her jaw was fused shut by a tumo...
American Adults Just Keep Getting Fatter
By MATT RICHTEL and ANDREW JACOBS from NYT Health http://ift.tt/2pyWd...
FOX NEWS: Scientists develop brain scanner in a helmet
Scientists develop brain scanner in a helmet
British scientists have developed a lightweight and highly sensitive brain imaging device that can be worn as a helmet, allowing the patient to move about naturall...
FOX NEWS: Freezing the 'hunger nerve' could help with weight loss, new study finds
Freezing the 'hunger nerve' could help with weight loss, new study finds
Researchers were able to freeze a nerve in the back that carries hunger signals to the brain, lowering patients' appetite and promoting weight los...
FOX NEWS: Wrestler and 'Dad bod destroyer' shows how you can use your kids as dumbbells
Wrestler and 'Dad bod destroyer' shows how you can use your kids as dumbbells
Professional wrestler Robbie E., father of 15-month-old twin boys, explains how he avoids the dad bod and combines play time with pump tim...
Thursday, March 22, 2018
FOX NEWS: Harry Connick Jr. talks colon cancer screening options
Harry Connick Jr. talks colon cancer screening options
Now that the Broadway crooner has turned 50, he is raising awareness on a cancer whose timely screening is crucial, colon cance...
FOX NEWS: ‘Childhood Alzheimer’s’ robs a teenager's ability to speak
‘Childhood Alzheimer’s’ robs a teenager's ability to speak
Levi Ormeroid, 19, can no longer talk or belt out the words to his favorite songs. The teenager was diagnosed with Sanfilippo syndrome, a rare genetic disorder which causes brain damage and is dubbed 'childhood Alzheimer’s' because of its similarity to the degenerative disease that typically...
FOX NEWS: Harry Connick Jr. and wife have ‘colonoscopy double date’?
Harry Connick Jr. and wife have ‘colonoscopy double date’?
Multi-talented musician, actor and TV host Harry Connick Jr. had a big cancer scare in 2012 when his wife Jill was diagnosed with breast cancer. Today, she is cancer free but credits routine screening with saving her life. Now that the Broadway crooner has turned 50, he’s raising awareness...
