FOX NEWS: Pain drugs in pregnancy tied to ADHD

Pain drugs in pregnancy tied to ADHD Women who use a lot of the common pain reliever acetaminophen during pregnancy may be more likely to have children with attention deficit hyperactivity disorder (ADHD) than those who don't use the drug, a Norwegian study suggest...

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Heartbeat: The potential power of genotype-phenotype correlations

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Interaction between body mass index and physical fitness in primary heart failure prevention

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Genotype-phenotype correlations in Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant connective-tissue disorder associated with abnormalities of the cardiovascular, ocular and musculoskeletal systems. Aortopathy, manifest as thoracic aortic aneurysm (TAA) and dissection, is the major cause of morbidity and mortality. Most individuals with MFS carry mutations in the gene FBN1. This gene encodes the extracellular matrix (ECM) protein fibrillin-1, which plays essential roles in the formation...

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Cochrane corner: renal denervation for resistant hypertension--a broken promise?

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Importance of the valve durability-life expectancy ratio in selection of a prosthetic aortic valve

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Management of Kawasaki disease in adults

Kawasaki disease is the most common childhood vasculitis in the USA and the most common cause of acquired cardiac disease in children in developed countries. Since the vast majority of Kawasaki disease initially presents at <5 years of age, many adult cardiologists are unfamiliar with the pathophysiology of this disease. This vasculitis has a predilection for coronary arteries with a high complication rate across the lifespan for those with medium...

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A current approach to heart failure in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a genetic, progressive neuromuscular condition that is marked by the long-term muscle deterioration with significant implications of pulmonary and cardiac dysfunction. As such, end-stage heart failure (HF) in DMD is increasingly becoming the main cause of death in this population. The early detection of cardiomyopathy is often challenging, due to a long subclinical phase of ventricular dysfunction and difficulties...

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Exertional dyspnoea in a 28-year-old woman

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Aerobic fitness, muscular strength and obesity in relation to risk of heart failure

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Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events

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Relationship between fibrillin-1 genotype and severity of cardiovascular involvement in Marfan syndrome

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Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism

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Effect of Fontan geometry on exercise haemodynamics and its potential implications

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Predictors of procedural complications in adult Fontan patients undergoing non-cardiac procedures

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Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes

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Transseptal puncture for structural heart intervention: an old technique with new indications

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Primary immune thrombocytopenia in adults: clinical practice versus management guidelines

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Hypertension: a weighty problem in children

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Variation in blood pressure among adolescent schoolchildren in an urban slum of Kolkata, West Bengal

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The implementation of cardiac arrest treatment recommendations in English acute NHS trusts: a national survey

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A longitudinal and multicentre study of burnout and error in Irish junior doctors

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Adequacy of postgraduate medical training: views of different generations of UK-trained doctors

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Assessing the use of magnetic resonance imaging virtopsy as an alternative to autopsy: a systematic review and meta-analysis

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Recent advances in the treatment of erectile dysfunction

Erectile dysfunction (ED) is one of the most common conditions affecting middle-aged and older men. Nearly every primary care physician, internist and geriatrician will be called upon to manage this condition or to make referrals to urologists, endocrinologists and cardiologists who will assist in the treatment of ED. This article will briefly discuss the diagnosis and management of ED. In addition, emerging concepts in ED management will be discussed,...

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Pattern of medication errors among inpatients in a resource-limited hospital setting

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Initial size of unilateral pleural effusion determines impact of thoracocentesis on oxygenation

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Systematic review and meta-analysis: tools for the information age

The amount of available biomedical information is vast and growing. Natural limitations of the way clinicians and researchers approach this treasure trove of information comprise difficulties locating the information, and once located, cognitive biases may lead to inappropriate use of the information. Systematic reviews and meta-analyses represent important tools in the information age to improve knowledge and action. Systematic reviews represent...

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Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature

Head neck squamous cell carcinomas (HNSCCs) are a significant cause of morbidity and mortality all around the world. Just like tobacco and alcohol, Human papilloma virus (HPV) infection is now recognized to play a role in the pathogenesis of a subset of HNSCCs. Unprotected sexual behaviours with the HPV carrier plays an important role in transmission of this virus. The global incidence of head and neck cancers is declining, but the incidence of HPV...

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An assessment of the public healthcare infrastructure deficiency in a district of Bihar state of India

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A case of metronidazole-induced neurotoxicity

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FOX NEWS: Mom diagnosed with breast cancer weeks after son starts leukemia treatment

Mom diagnosed with breast cancer weeks after son starts leukemia treatment A mother is sharing how her 9-year-old son was diagnosed with leukemia twice, just six weeks before she found out she had breast cance...

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FOX NEWS: Florida resident dies of rabies from bat bite, health official says

Florida resident dies of rabies from bat bite, health official says Florida health officials announced that a resident has died as a result of rabies after being bitten by a ba...

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Retinopathy in an obesity WHO III cohort: prevalence and risk factors

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Peripheral fundus findings in X-linked retinoschisis

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Rectus muscle excyclorotation and V-pattern strabismus: a quantitative appraisal of clinical relevance in syndromic craniosynostosis

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Cancer-associated epiphora: a retrospective analysis of referrals to a tertiary oculoplastic practice

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Small incision guarded hydroaspiration of iris lesions

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Serum IgG2 and tissue IgG2 plasma cell elevation in orbital IgG4-related disease (IgG4-RD): Potential use in IgG4-RD assessment.

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Paracrine effects of mesenchymal stem cells on the activation of keratocytes

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70 years of the JCP-highly cited papers: Proposals for the classification of chronic (mature) B and T lymphoid leukaemias

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Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice

Primary aldosteronism (PA) is the most common form of secondary hypertension and is critical to identify because when caused by an aldosterone-producing adenoma (APA) or another unilateral form, it is potentially curable, and even when caused by bilateral disease, antihypertensives more specific to PA treatment can be employed (ie, aldosterone antagonists). Identification of unilateral forms is not generally accomplished with imaging because APAs...

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Cutaneous angiosarcoma: a current update

Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or ‘mimickers’. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted...

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Characterisation of GATA3 expression in invasive breast cancer: differences in histological subtypes and immunohistochemically defined molecular subtypes

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This Months Highlights

from Journal of the American Society of Nephrology current issue http://ift.tt/2iPVm...

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Ets in the Kidney--Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension

from Journal of the American Society of Nephrology current issue http://ift.tt/2zmV8...

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New Insights into Fuel Choices of Nephron Progenitor Cells

from Journal of the American Society of Nephrology current issue http://ift.tt/2iNPL...

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Extracellular Vesicles in Preeclampsia: Evolving Contributors to Proteinuria

from Journal of the American Society of Nephrology current issue http://ift.tt/2zmqv...

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Why Diuretics Fail Failing Hearts

from Journal of the American Society of Nephrology current issue http://ift.tt/2iPmG...

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Transplantation of Kidneys from HCV-Positive Donors: How to Best Use a Scarce Resource

from Journal of the American Society of Nephrology current issue http://ift.tt/2zmyB...

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Kidney Disease in HIV: Moving beyond HIV-Associated Nephropathy

In developed countries, remarkable advances in antiretroviral therapy have transformed HIV infection into a chronic condition. As a result, HIV-associated nephropathy, the classic HIV-driven kidney lesion among individuals of African descent, has largely disappeared in these regions. However, HIV-positive blacks continue to have much higher rates of ESRD than HIV-positive whites, which could be attributed to the APOL1 renal risk variants. Additionally,...

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How Dangerous Is Hyperkalemia?

Hyperkalemia is a potentially life-threatening electrolyte disorder appreciated with greater frequency in patients with renal disease, heart failure, and with use of certain medications such as renin angiotensin aldosterone inhibitors. The traditional views that hyperkalemia can be reliably diagnosed by electrocardiogram and that particular levels of hyperkalemia confer cardiotoxic risk have been challenged by several reports of patients with atypic...

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The Evolving Complexity of the Podocyte Cytoskeleton

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease....

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Mannose-Binding Lectin Levels Could Predict Prognosis in IgA Nephropathy

IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of MBL in IgAN. Here, we measured MBL2 variants and MBL levels in 749 patients with IgAN and 489 healthy controls. Overall, 5.2% (39 of 749) of patients with IgAN had MBL deficiency (MBL levels <100 ng/ml), among...

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Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy

Established therapies for diabetic nephropathy (dNP) delay but do not prevent its progression. The shortage of established therapies may reflect the inability to target the tubular compartment. The chemical chaperone tauroursodeoxycholic acid (TUDCA) ameliorates maladaptive endoplasmic reticulum (ER) stress signaling and experimental dNP. Additionally, TUDCA activates the farnesoid X receptor (FXR), which is highly expressed in tubular cells. We...

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Endothelial NF-{kappa}B Blockade Abrogates ANCA-Induced GN

ANCA-associated vasculitis (AAV) is a highly inflammatory condition in which ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis. We tested the hypothesis that endothelial NF-B mediates necrotizing crescentic GN (NCGN) and provides a specific treatment target. Reanalysis of kidneys from previously examined murine NCGN disease models revealed NF-B activation in affected kidneys, mostly as a p50/p65 heterodimer,...

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Hepatocyte Nuclear Factor-1{beta} Controls Mitochondrial Respiration in Renal Tubular Cells

AKI is a frequent condition that involves renal microcirculation impairment, infiltration of inflammatory cells with local production of proinflammatory cytokines, and subsequent epithelial disorders and mitochondrial dysfunction. Peroxisome proliferator-activated receptor coactivator 1-α (PPARGC1A), a coactivator of the transcription factor PPAR- that controls mitochondrial biogenesis and function, has a pivotal role in the early dysfunction of...

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Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts

The normal response to kidney injury includes a robust inflammatory infiltrate of PMNs and macrophages. We previously showed that the small secreted protein breast regression protein–39 (BRP-39), also known as chitinase 3–like 1 (CHI3L1) and encoded by the Chi3l1 gene, is expressed at high levels by macrophages during the early stages of kidney repair and promotes tubular cell survival via IL-13 receptor α2 (IL13Rα2)–mediated signaling. Here, we...

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Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

Population genetic approaches have uncovered a strong association between kidney diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and variant G2, compared with the nonrisk G0 allele. However, the mechanism whereby these variants lead to disease manifestation and, in particular, whether this involves an intracellular or extracellular pool of APOL1 remains unclear. Herein, we show a predominantly intracellular localization...

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Haploinsufficiency of the Transcription Factor Ets-1 Is Renoprotective in Dahl Salt-Sensitive Rats

Studies using Dahl salt-sensitive (SS) rats identified specific quantitative trait loci that predispose animals to hypertension-associated albuminuria and kidney injury. We explored the hypothesis that kidney-specific expression of the transcription factor Ets-1, located within one of these loci on chromosome 8, mediates glomerular injury in SS hypertension. During the first week on a high-salt diet, SS rats and SS rats with only one functioning...

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MicroRNA-92a Mediates Endothelial Dysfunction in CKD

CKD is an independent risk factor for cardiovascular disease (CVD). The accumulation of uremic toxins in CKD induces oxidative stress and endothelial dysfunction. MicroRNA-92a (miR-92a) is induced by oxidative stress in endothelial cells (ECs) and involved in angiogenesis and atherosclerosis. We investigated a role for oxidative stress–responsive miR-92a in CKD. Our study of patients at three clinical sites showed increased serum miR-92a level with...

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A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

Thrombospondin type 1 domain-containing 7A (THSD7A) is a target for autoimmunity in patients with membranous nephropathy (MN). Circulating autoantibodies from patients with THSD7A-associated MN have been demonstrated to cause MN in mice. However, THSD7A-associated MN is a rare disease, preventing the use of patient antibodies for larger experimental procedures. Therefore, we generated antibodies against the human and mouse orthologs of THSD7A in...

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Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis

In damaged kidneys, increased extracellular matrix (ECM) and tissue stiffness stimulate kidney fibrosis through incompletely characterized molecular mechanisms. The transcriptional coactivators yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) function as mechanosensors in cancer cells and have been implicated in the regulation of myofibroblasts in the kidney. We hypothesized that the development of kidney...

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A Missense Mutation in the Extracellular Domain of {alpha}ENaC Causes Liddle Syndrome

Liddle syndrome is an autosomal dominant form of hypokalemic hypertension due to mutations in the β- or -subunit of the epithelial sodium channel (ENaC). Here, we describe a family with Liddle syndrome due to a mutation in αENaC. The proband was referred because of resistant hypokalemic hypertension, suppressed renin and aldosterone, and no mutations in the genes encoding β- or ENaC. Exome sequencing revealed a heterozygous, nonconservative T>C...

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Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model

Lysophosphatidic acid (LPA) functions through activation of LPA receptors (LPARs). LPA–LPAR signaling has been implicated in development of fibrosis. However, the role of LPA–LPAR signaling in development of diabetic nephropathy (DN) has not been studied. We examined whether BMS002, a novel dual LPAR1 and LPAR3 antagonist, affects development of DN in endothelial nitric oxide synthase-knockout db/db mice. Treatment of these mice with BMS002 from...

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PGC-1{alpha} Protects from Notch-Induced Kidney Fibrosis Development

Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in fibrosis development. The molecular mechanism of Notch-induced fibrosis, however, remains poorly understood. Here, we show that, that expression of peroxisomal proliferation g-coactivator (PGC-1α) and fatty acid oxidation-related genes are lower in mice expressing active...

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Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism

Nephron progenitor cells (NPCs) show an age-dependent capacity to balance self-renewal with differentiation. Older NPCs (postnatal day 0) exit the progenitor niche at a higher rate than younger (embryonic day 13.5) NPCs do. This behavior is reflected in the transcript profiles of young and old NPCs. Bioenergetic pathways have emerged as important regulators of stem cell fate. Here, we investigated the mechanisms underlying this regulation in murine...

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Association between Endothelin-1 Levels and Kidney Disease among Blacks

Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology. It is not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in the general population. In participants in the Jackson Heart Study, a community-based observational study of cardiovascular risk in black adults, we measured serum endothelin-1 level at baseline...

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The Loss of GSTM1 Associates with Kidney Failure and Heart Failure

Glutathione S-transferase mu 1 (GSTM1) encodes an enzyme that catalyzes the conjugation of electrophilic compounds with glutathione to facilitate their degradation or excretion. The loss of one or both copies of GSTM1 is common in many populations and has been associated with CKD progression. With the hypothesis that the loss of GSTM1 is also associated with incident kidney failure and heart failure, we estimated GSTM1 copy number using exome sequencing...

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Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development

Despite more than two decades of use, the optimal maintenance dose of tacrolimus for kidney transplant recipients is unknown. We hypothesized that HLA class II de novo donor-specific antibody (dnDSA) development correlates with tacrolimus trough levels and the recipient’s individualized alloimmune risk determined by HLA-DR/DQ epitope mismatch. A cohort of 596 renal transplant recipients with 50,011 serial tacrolimus trough levels had HLA-DR/DQ eplet...

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Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia

Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We hypothesized that renal expression of podocyte-specific proteins would be reflected in urinary extracellular vesicles (EVs) of podocyte origin and accompanied by increased urinary soluble nephrin levels (nephrinuria) in preeclampsia. We further postulated that podocyte injury and attendant formation...

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Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery

Urinary matrix metalloproteinase-7 (uMMP-7) levels consistently reflect the activity of intrarenal Wnt/β-catenin, which is activated in AKI models. To test the hypothesis that uMMP-7 is a predictor for severe AKI in patients after cardiac surgery, we performed a prospective, multicenter, two-stage cohort study in 721 patients undergoing cardiac surgery. In stage 1, we enrolled 323 children from three academic medical centers. In stage 2, we enrolled...

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Association Analysis of the MHC in Lupus Nephritis

Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we performed a comprehensive sequencing analysis of the whole MHC region in 1331 patients with LN and 1296 healthy controls and validated the independent...

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Characterization and Correction of Olfactory Deficits in Kidney Disease

Patients with CKD suffer from food aversion, anorexia, and malnutrition. Although olfaction has a significant role in determining food flavor, our understanding of olfactory impairment and of the olfaction-nutrition axis in patients with kidney disease is limited. We quantified odor identification, odor threshold, and subjective odor perception in a cohort (n=161) comprising 36 participants with CKD, 100 participants with ESRD, and 25 controls. We...

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FOX NEWS: Michigan woman makes Halloween costumes for NICU babies

Michigan woman makes Halloween costumes for NICU babies A Michigan woman is giving the babies in Beaumont Hospital- Royal Oak’s NICU a special treat this Hallowee...

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FOX NEWS: What to know about the rise of oral HPV cases in men

What to know about the rise of oral HPV cases in men Recent studies suggest that men have a particularly high prevalence of high-risk oral human papillomaviruses (HPV), which can lead to cance...

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FOX NEWS: NICU babies at Kansas City hospital celebrate Halloween in adorable outfits

NICU babies at Kansas City hospital celebrate Halloween in adorable outfits Babies spending their first Halloween in a Missouri neonatal intensive care unit celebrated the holiday dressed as superheroes and butterflie...

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FOX NEWS: New Jersey authorities warn of marijuana-laced Halloween candy

New Jersey authorities warn of marijuana-laced Halloween candy The New Jersey attorney general's office has warned parents to check for marijuana-laced Halloween cand...

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FOX NEWS: High school football player died of 'blunt force trauma'

High school football player died of 'blunt force trauma' The death of a 16-year-old football player has been attributed to “blunt force trauma,” and ruled accidental after he collapsed during a blocking play in an Oct. 20 gam...

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FOX NEWS: Mom diagnosed with breast cancer weeks after son starts leukemia treatment

Mom diagnosed with breast cancer weeks after son starts leukemia treatment A mother is sharing how her 9-year-old son was diagnosed with leukemia twice, just six weeks before she found out she had breast cance...

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FOX NEWS: Florida resident dies of rabies from bat bite, health official says

Florida resident dies of rabies from bat bite, health official says Florida health officials announced that a resident has died as a result of rabies after being bitten by a ba...

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FOX NEWS: Sorority sister dies 3 weeks after getting hit in head by soccer ball

Sorority sister dies 3 weeks after getting hit in head by soccer ball A University of Alabama freshman will be remembered during a prayer vigil on Wednesday, days after she died from a soccer injury that left her in a coma for three week...

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FOX NEWS: FDA moves to revoke claim that soy protein protects the heart

FDA moves to revoke claim that soy protein protects the heart The U.S. Food and Drug Administration on Monday proposed a rule revoking the right of companies to claim soy protein protects the heart, while potentially allowing a more circumspect health clai...

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FOX NEWS: Pain drugs in pregnancy tied to ADHD

Pain drugs in pregnancy tied to ADHD Women who use a lot of the common pain reliever acetaminophen during pregnancy may be more likely to have children with attention deficit hyperactivity disorder (ADHD) than those who don't use the drug, a Norwegian study suggest...

Read More

FOX NEWS: Pre-Halloween warning: FDA warns about too much black licorice

Pre-Halloween warning: FDA warns about too much black licorice If you’re planning to stash up on black licorice for Halloween, the Food and Drug Administration (FDA) issued a warning on Monday about possible dangerous side effects of the old-fashioned favorit...

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A Lesson From the Biggest Losers: Exercise Keeps Off the Weight

By GINA KOLATA from NYT Health http://ift.tt/2zVwS...

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FOX NEWS: How bedbugs could be the culprit for anemia

How bedbugs could be the culprit for anemia Nobody in their right mind likes a bed bu...

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What Experts Know About Men Who Rape

By HEATHER MURPHY from NYT Health http://ift.tt/2A22K...

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FOX NEWS: Indiana mom whose overdose photo went viral announces she's one year sober

Indiana mom whose overdose photo went viral announces she's one year sober Last year, authorities in Hope, Indiana released pictures of Erika Hurt, a woman found overdosed behind the wheel in the Dollar General parking lo...

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FOX NEWS: Everything you need to know about breast cysts

Everything you need to know about breast cysts Just because you found a lump doesn't mean it's cance...

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FOX NEWS: Leaking lighter removed from patient's stomach

Leaking lighter removed from patient's stomach One Florida man's stomach pain turned out to have an unusual cause: A lighter that the man had swallowed was leaking lighter fluid into his gut, according to a recent report of the man's cas...

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FOX NEWS: Recurrent concussions are down in high school sports

Recurrent concussions are down in high school sports With passage of laws requiring U.S. high schools to report young athletes' concussions, more of these head injuries are being reported - but the rate of repeat concussions has gone down, a new study show...

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FOX NEWS: Bears tight end undergoes emergency surgery after gruesome leg injury

Bears tight end undergoes emergency surgery after gruesome leg injury Chicago Bears tight end Zach Miller underwent emergency surgery on Sunday night after suffering a gruesome injury to his knee that reportedly him in danger of losing his le...

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FOX NEWS: Bears tight end reportedly undergoes emergency surgery after gruesome leg injury

Bears tight end reportedly undergoes emergency surgery after gruesome leg injury Chicago Bears tight end Zach Miller underwent emergency surgery on Sunday night after suffering a gruesome injury to his knee that reportedly him in danger of losing his le...

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FOX NEWS: Parents share heartbreaking photos of baby set to lose limbs to meningitis

Parents share heartbreaking photos of baby set to lose limbs to meningitis The parents of a baby struck by meningitis have been told she will lose all of her limbs, her sight and hearing and suffer 90 percent brain damage in the worst case doctors have seen in 25 year...

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FOX NEWS: Georgia boy, 2, blocked from getting father's kidney, is rushed to hospital

Georgia boy, 2, blocked from getting father's kidney, is rushed to hospital A 2-year-old Georgia boy who was unable to receive his father’s kidney for a transplant after it was discovered he violated his probation was rushed to an emergency room Sunday morning after suffering an abdominal infectio...

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FOX NEWS: Arizona seeing 100 opioid deaths per month, data show

Arizona seeing 100 opioid deaths per month, data show Opioids have claimed more than 400 lives in Arizona since June 15 alone, a state database has reveale...

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FOX NEWS: Woman sues for $1.8M over hysterectomy, mastectomy

Woman sues for $1.8M over hysterectomy, mastectomy An Oregon woman is seeking $1.8 million after she says multiple medical professionals misread test results, resulting in her getting a double mastectomy and hysterectomy last year, the Oregonian report...

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The Governor Blocked Medicaid Expansion. Now Maine Voters Could Overrule Him.

By ABBY GOODNOUGH from NYT Health http://ift.tt/2yRar...

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FOX NEWS: Teen's sore throat spirals into life-threatening infection

Teen's sore throat spirals into life-threatening infection A complaint about a sore throat has turned into a health nightmare for one Rhode Island teen, who is now reportedly facing partial amputation of her right le...

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Jewish Philanthropists Create a Prize for Christian Missionaries

By DONALD G. McNEIL Jr. from NYT Health http://ift.tt/2iEUB...

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FOX NEWS: New therapy 'rewires' the brain to fight depression

New therapy 'rewires' the brain to fight depression Medications don’t always help patients suffering from depression, in fact studies show they can be ineffective in up to 40 percent of all patients. Doctors at UCLA Health are offering a new drug-free treatment for people with depressio...

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FOX NEWS: 1-year-old dies after ingesting powerful synthetic opioid

1-year-old dies after ingesting powerful synthetic opioid A 1-year-old girl who died in August was exposed to a powerful synthetic opioid that is typically used as a sedative for elephant...

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One Last Question Before the Operation: Just How Frail Are You?

By PAULA SPAN from NYT Health http://ift.tt/2xtRM...

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FOX NEWS: 8-year-old skips birthday presents, asks for donations for toddler with rare illness

8-year-old skips birthday presents, asks for donations for toddler with rare illness Rather than throw a big birthday party complete with presents and fanfare, Brooklynn Daniel, who turns 8 on Friday, wants guests who attend her bash to donate to the Foundation for Prader-Willi Research in honor of Evan Brenneman, her 22-month-old frien...

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FOX NEWS: Nurse serenades dying patient with her favorite song

Nurse serenades dying patient with her favorite song More than 3 million people have watched a nurse in Tennessee serenade her dying patient with her favorite song after the woman’s daughter captured the emotional moment on video, and shared it on Faceboo...

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FOX NEWS: Harvey Weinstein scandal led to increase in hotline calls, RAINN officials say

Harvey Weinstein scandal led to increase in hotline calls, RAINN officials say A national sexual assault hotline has reported a record number of increased calls in the wake of the Harvey Weinstein scanda...

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Heartbeat: The potential power of genotype-phenotype correlations

...

Read More

Interaction between body mass index and physical fitness in primary heart failure prevention

...

Read More

Genotype-phenotype correlations in Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant connective-tissue disorder associated with abnormalities of the cardiovascular, ocular and musculoskeletal systems. Aortopathy, manifest as thoracic aortic aneurysm (TAA) and dissection, is the major cause of morbidity and mortality. Most individuals with MFS carry mutations in the gene FBN1. This gene encodes the extracellular matrix (ECM) protein fibrillin-1, which plays essential roles in the formation...

Read More

Cochrane corner: renal denervation for resistant hypertension--a broken promise?

...

Read More

Importance of the valve durability-life expectancy ratio in selection of a prosthetic aortic valve

...

Read More

Management of Kawasaki disease in adults

Kawasaki disease is the most common childhood vasculitis in the USA and the most common cause of acquired cardiac disease in children in developed countries. Since the vast majority of Kawasaki disease initially presents at <5 years of age, many adult cardiologists are unfamiliar with the pathophysiology of this disease. This vasculitis has a predilection for coronary arteries with a high complication rate across the lifespan for those with medium...

Read More

A current approach to heart failure in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a genetic, progressive neuromuscular condition that is marked by the long-term muscle deterioration with significant implications of pulmonary and cardiac dysfunction. As such, end-stage heart failure (HF) in DMD is increasingly becoming the main cause of death in this population. The early detection of cardiomyopathy is often challenging, due to a long subclinical phase of ventricular dysfunction and difficulties...

Read More

Exertional dyspnoea in a 28-year-old woman

...

Read More

Aerobic fitness, muscular strength and obesity in relation to risk of heart failure

...

Read More

Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events

...

Read More

Relationship between fibrillin-1 genotype and severity of cardiovascular involvement in Marfan syndrome

...

Read More

Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism

...

Read More

Effect of Fontan geometry on exercise haemodynamics and its potential implications

...

Read More

Predictors of procedural complications in adult Fontan patients undergoing non-cardiac procedures

...

Read More

Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes

...

Read More

Transseptal puncture for structural heart intervention: an old technique with new indications

...

Read More

FOX NEWS: Identity theft victim stunned by $52G hospital bill: report

Identity theft victim stunned by $52G hospital bill: report A San Francisco man who had his backpack stolen with ID cards got a bill $52,310 bill from a hospital for a procedure that he never had done, The San Francisco Chronicle reporte...

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FOX NEWS: The emergency declaration was a start. Here’s how else Trump plans to combat the opioid epidemic

The emergency declaration was a start. Here’s how else Trump plans to combat the opioid epidemic Trump laid out ways in which his administration would be attempting to combat the opioid epidemic in the coming weeks and month...

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FOX NEWS: 5 early signs of lung cancer you shouldn't ignore

5 early signs of lung cancer you shouldn't ignore You might dismiss lung cancer because you don’t smoke or because you live in a less polluted are...

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FOX NEWS: California woman, 45, in 'shock' after unexpectedly giving birth

California woman, 45, in 'shock' after unexpectedly giving birth A 45-year-old woman in California reportedly gave birth to a surprise baby boy after not realizing she was even pregnan...

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FOX NEWS: Study finds arsenic, BPA and lead in baby food products

Study finds arsenic, BPA and lead in baby food products A study which looked at hundreds of baby food products found that 65 percent of the items tested positive for the dangerous chemical element arsenic, according to the Clean Label Projec...

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FOX NEWS: Baby born with vocal cords fused together says 'dada' for the first time

Baby born with vocal cords fused together says 'dada' for the first time A baby girl born with her vocal cords fused together said "dada" for the first time in a precious clip captured by her parent...

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FOX NEWS: Puppy that collapsed on walk is saved with overdose antidote

Puppy that collapsed on walk is saved with overdose antidote A puppy that collapsed after ingesting some sort of opioid in Massachusetts has survived after being given an overdose reversal drug more often administered to human...

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FOX NEWS: 9-year-old battling brain cancer serenades fellow patients during treatment

9-year-old battling brain cancer serenades fellow patients during treatment A 9-year-old girl being treated for an aggressive form of brain cancer is bringing joy to patients around her with her love of musi...

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FOX NEWS: Walgreens to begin stocking Narcan in pharmacies nationwide

Walgreens to begin stocking Narcan in pharmacies nationwide Walgreens announced on Tuesday that it will begin stocking noloxone, the FDA-approved nasal spray sold under the brand Narcan and used to reverse the effects of an opioid overdose, in all of its pharmacies nationwid...

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The Opioid Epidemic: What You Need to Know

By YOUSUR AL-HLOU, JOSH KATZ and DREW JORDAN from NYT Health http://ift.tt/2y7yj...

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FOX NEWS: First test of anti-epilepsy surgeries in children shows dramatic benefit

First test of anti-epilepsy surgeries in children shows dramatic benefit Brain surgery for children whose epilepsy is resistant to drug therapy can produce a 10-fold increase in the odds of being seizure-free after one year and can do it without affecting IQ, according to a new Indian study of 116 patients in The New England Journal of Medicin...

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FOX NEWS: Rhode Island doctor pleads guilty to opioid kickback scheme related to Insys

Rhode Island doctor pleads guilty to opioid kickback scheme related to Insys A Rhode Island doctor pleaded guilty on Wednesday to charges he participated in a scheme to obtain kickbacks in exchange for writing prescriptions for an addictive fentanyl-based cancer pain drug produced by Insys Therapeutics In...

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FOX NEWS: FDA approves intravenous version of Tesaro drug for chemotherapy nausea

FDA approves intravenous version of Tesaro drug for chemotherapy nausea Tesaro Inc said on Wednesday that the U.S. Food and Drug Administration approved an intravenous version of its drug to treat chemotherapy-induced nausea and vomiting in adult...

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FOX NEWS: High cholesterol levels among US adults declining, CDC reports

High cholesterol levels among US adults declining, CDC reports The prevalence of U.S. adults with high cholesterol declined significantly between 1999-2000 and 2015-2016, achieving a long-term public health goal, according to data released on Thursday by the Centers for Disease Control and Prevention's National Center for Health Statistic...

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